Evidence Synthesis for Life Sciences Organizations

Software for Evidence Synthesis

Cross-Functional Evidence Platform

Transform your evidence generation and synthesis capabilities with AI-powered automation across every function. Nested Knowledge helps pharmaceutical and medical device companies streamline systematic literature reviews, evidence synthesis, and insights generation throughout the product lifecycle.

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Nested Knowledge Software

Nested Knowledge® offers a comprehensive platform for executing, analyzing, and sharing any review type, from rapid to systematic. In AutoLit®, Search, screen, and extract data with human-in-the-loop AI assistance. Complete rapid reviews in under 30 minutes, or save over 70% of time on systematic reviews. For every project, your Synthesis page will be created automatically, enabling you to visualize, analyze, publish, embed, and share insights from your project, giving you and your team a Living Evidence Library on your key topics of interest.

support

Everyone Needs Evidence Synthesis

Strategy & Intelligence
Use Case
  • Automated landscape assessment
  • Competitive intelligence reviews
  • Gap analysis
  • Integrated evidence planning
Case Study: Exploring Biological Mechanisms
Our platform enables researchers to efficiently analyze complex biological mechanisms, such as neurodegeneration pathways.
Read the case study →
Features
  • AI-powered synthesis
  • Real-time monitoring
  • Interactive visualizations
  • Inclusion Criteria and Endpoint Mapping
Ways to Work
Nested Knowledge Enterprise Plus™ - Advanced AI capabilities for strategic decision support.

Partner Network - Access our network of specialized evidence synthesis service providers. View Evidence Synthesis Services →
Clinical & Regulatory Affairs
Use Case
  • Phase II/III trial planning
  • Clinical Evaluation Reports (CERs)
  • Regulatory responses
Case Study: Feasibility for Clinical Trial
Our platform helped optimize clinical trial design through comprehensive evidence synthesis and feasibility assessment.
Read the case study →
Features
  • Protocol optimization
  • Submission document generation
  • Living literature surveillance
Ways to Work
Nested Knowledge Enterprise Plus™ - Advanced AI capabilities and powerful workflows.

Partner Network - Access our network of specialized evidence synthesis service providers. View Evidence Synthesis Services →
Medical Affairs
Use Case
  • Scientific Communication Platform development
  • Advisory Board preparation
  • Indication exploration
Case Study: Expanded Uses of Asset
Our platform supported the development of expanded use cases for ATGAM in renal transplantation, helping medical affairs teams effectively communicate evidence.
Download ATGAM poster (PDF)
Features
  • KOL insights mapping
  • Publication planning
  • AI-assisted Targeted Literature Review
  • Auto-generated synthesis outputs
Ways to Work
Nested Knowledge Enterprise Plus™ - Automate Evidence Generation and Insights.

Partner Network - Access our network of specialized evidence synthesis service providers.

Technical Integration Options - Envision Pharma Group
Read About Our Envision Partnership →
Market Access & HEOR
Use Case
  • Evidence Synthesis for HTA submission support
  • Clinical/Economic/Humanistic systematic literature reviews
Case Study: Living Libraries across Therapeutic Areas
Our platform enabled CROs to generate recurring revenue through continuously updated evidence libraries across multiple therapeutic areas.
Read the case study →
Features
  • Full, AI-supported Workflow - Search, Screening, Extraction, Critical Appraisal
  • Templates for key geographies
  • Audit-ready exports
  • Living, web-based visuals
Ways to Work
Nested Knowledge Enterprise Plus™ - HTA-ready workflows & Responsible use of AI.

Partner Network - Access our network of specialized evidence synthesis service providers.

Technical Integration Options - DoBO from MArS Market Access
Read About Our MArS Partnership →
Real World Evidence
Use Case
  • Computable phenotype development
  • Validation cohort identification
Case Study: Computable Operational Definitions
Our partnership with Navidence standardizes real-world evidence computable operational definitions for improved data interoperability.
Request Case Study
Features
  • Search for published RWE studies
  • Code List and Validation extraction
  • Flexible external source addition
Ways to Work
Nested Knowledge Enterprise Plus™ - Literature-driven Real World Evidence design.

Partner Network - Access our network of specialized evidence synthesis service providers.

Technical Integration Options - Navidence.
Read About Our Navidence Partnership →

Living Evidence Library

  • Conventional reviews result in, at best, a static Excel sheet for future reference.
  • Replace these reviews with Living Evidence Libraries, created automatically in Synthesis as soon as you execute any project in AutoLit®.
  • Reviews in Nested Knowledge go beyond the literature: add in active trials, real-world data, and internal data to understand the full evidence landscape in your therapeutic area.
  • Each Synthesis page contains visual qualitative and quantitative tools, including network meta-analyses for every endpoint), with the ability to build custom, exportable Dashboards.
  • Own your reviews: If you own the ‘nest’ in Nested Knowledge, you can easily edit, update, and build upon your existing work, allowing you to share, expand, and refresh critical evidence throughout the product lifecycle.

Seamless Integration

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We will work with you from day one to ensure a seamless transition to new ways of working. Our unified evidence architecture connects teams, automates workflows with AI, and drives insights across your organization. With enterprise-grade security and compliance features, Nested Knowledge seamlessly integrates into your existing processes while dramatically improving efficiency.

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