Health Economics
& Outcomes Research

Software for Evidence Synthesis

Uncover Value for the Entire Organization

Nested Knowledge® enables HEOR professionals to build the single source of truth for comparing and presenting clinical outcomes research. Provide payers––and your entire team––with the evidence they need using a living evidence strategy that incorporates the value assessment frameworks across different markets. By conducting your evidence synthesis in Nested Knowledge, from network meta-analyses of clinical trial data, to systematic or even scoping reviews across diverse data sources, you are creating the single living source for all future analysis and reporting of crucial clinical data.

Epidemiological Data

Understand the incidence and prevalence of a disease across populations to define the impact of the intervention.

Clinical Comparisons

Compare the intervention under review with comparators to ascertain the safety and efficacy relative to similar interventions.

Economic Model Data

Gather the quantitative metrics needed to generate economic models, cost, utilization, and utility data as required by NICE.

Quality Assessment

Appraise the quality of evidence across all reviews, with templates for a variety of frameworks and evidence types.

Living Evidence

HTA Bodies Demand Quality

Systematic reviews and meta-analysis have long been a requirement for Health Technology Assessment (HTA) submissions across the international regulatory landscape. Some markets are moving toward adoption of joint clinical assessment (JCA) methodologies which, while more unified, may be more stringent than current standards and will eventually integrate with regulatory reviews.

Understand how to gather the right evidence with templates from Nested Knowledge.

Inform multiple departments, from R&D to marketing, throughout the client’s organization. Unlock new, recurring revenue streams by providing targeted insights over the entire product lifecycle.

Living HTA

How do you keep up? The future is living evidence.

HTAs are typically performed as one-off evaluations but rapidly become out-of-date due to the availability of new data, new comparators, or other factors.

Recently, living approaches have been applied to systematic reviews and network meta-analyses to enable evidence syntheses to be updated more easily…such a living approach could be applied to the entire HTA process.

Thokala P, Srivastava T, Smith R, Ren S, Whittington MD, Elvidge J, Wong R, Uttley L. Living Health Technology Assessment: Issues, Challenges and Opportunities. Pharmacoeconomics. 2023 Mar;41(3):227-237. doi: 10.1007/s40273-022-01229-4. Epub 2023 Jan 18. PMID: 36652184; PMCID: PMC9848020.

Tools for Ongoing Analysis

Living Evidence Libraries

By centralizing all of the relevant data in a single, easily accessible platform, Nested Knowledge allows HEOR teams to continuously synthesize in the background, while offering instant, curated access on to key stakeholders.

Keep everyone on the same page throughout the entire product lifecycle, for every product in your portfolio.

See it in Action

Experience Living Evidence

This interactive Qualitative Synthesis visualization results from the careful combination of all currently available and published evidence for treatment of Basilar Artery Stroke with Endovascular Thrombectomy. Updated continuously in the background, this point-and-click interface allows you to review hand-picked insights, then explore the sunburst diagram or select a specific study to trace insights back to the source.

By creating the best systematic review, meta-analysis, and evidence synthesis tools available, Nested Knowledge allows you and your clients to focus on analyzing the outcomes associated with interventions and comparators across populations.

Start tracking hundreds of variables concurrently with Nested Knowledge.

Global impact

Deploy Nested Knowledge

Living evidence enables you serve all markets, both familiar and new, simultaneously.

  • SLR of clinical data for the technology and its comparators
  • Critical appraisal of RCTs and non-RCTs
  • SLR of economic models for technology
  • Critical appraisal of economic models
  • SLR of utility data
  • SLR of resource use and cost data
  • Epidemiological Data

Get in touch with our client success team: