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Systematic Review Basics:
A systematic review follows a very similar structure to that of other clinical publications. It typically includes a title, abstract, introduction, methods, results, discussion, and references. The difference lies in how the underlying evidence is compiled.
Nested Knowledge is designed to support multiple types of industry standard workflows for the entire life-cycle of a systematic review. Conducting a systematic review usually means conducting a literature search, screening records, tagging records, extracting data, critical appraisal (Risk of Bias) and reporting the results. Nested Knowledge supports all of these steps, adds additional dual modes to meet the rigorous requirements of research teams, and keeps track of each step of the process, to eliminate redundant work.
With the advent of dedicated, comprehensive software like Nested Knowledge, anyone can complete a systematic review. Some review types may require more than one reviewer, however.
The time it takes to complete a systematic review depends on the number of studies in the review as well as the number of tags and data elements in your study design. The more qualitative and quantitative data you gather, the longer your review will take. For more involved reviews like Meta-Analyses, see PredicTER. For time estimates, Nested Knowledge will greatly expedite your Search, Screening, and Extraction steps.
The size of your review depends on numerous factors, including: the volume and quality of published research in your domain, the breadth of your research question, and the scoping & constraints placed on your project. We recommend generating early upper bounds on search size by running a broad search, and extrapolating number of inclusions using initial screening.
Nested Knowledge makes it possible to conduct all major types of systematic reviews, including scoping reviews, rapid reviews, narrative reviews, meta-analyses, mixed methods reviews, and many others.
Evidence-based medicine is the notion that doctors and other healthcare providers should make decisions based on the highest quality evidence available. Generally, “in the hierarchy of evidence, systematic reviews including meta-analysis of methodologically sound RCTs with consistent results, are considered the highest level of evidence” (Guyatt, 1995)
A PRISMA diagram will be automatically generated if you complete your literature search and screening in Nested Knowledge. Click Here for more.
Nested Knowledge Basics:
Nested Knowledge allows you to complete every step of a systematic literature review and meta-analysis in one place, then automatically generates interactive visuals based on your review. Learn more about us!
Health Economics and Outcomes Research (HEOR), Systematic Literature Reviews (SLR), Clinical Evaluation Reports (CER)… Learn more here!
Completing a CER can feel overwhelming, but you can use Nested Knowledge to dramatically speed up the process of gathering clinical evidence using question tags.