Create and Share Your Systematic Review on the Internet!

Frequently Asked Questions

Find answers to the questions we're frequently asked about

Systematic Review Basics:

A systematic review follows a very similar structure to that of other clinical publications. It typically includes a title, abstract, introduction, methods, results, discussion, and references. The difference lies in how the underlying evidence is compiled.

Nested Knowledge is designed to support multiple types of industry standard workflows for the entire life-cycle of a systematic review. Conducting a systematic review usually means conducting a literature search, screening records, tagging records, extracting data, critical appraisal (Risk of Bias) and reporting the results. Nested Knowledge supports all of these steps, adds additional dual modes to meet the rigorous requirements of research teams, and keeps track of each step of the process, to eliminate redundant work.

With the advent of dedicated, comprehensive software like Nested Knowledge, anyone can complete a systematic review. Some review types may require more than one reviewer, however.

The time it takes to complete a systematic review depends on the number of studies in the review as well as the number of tags and data elements in your study design. The more qualitative and quantitative data you gather, the longer your review will take. For more involved reviews like Meta-Analyses, see PredicTER. For time estimates, Nested Knowledge will greatly expedite your Search, Screening, and Extraction steps.

The size of your review depends on numerous factors, including: the volume and quality of published research in your domain, the breadth of your research question, and the scoping & constraints placed on your project. We recommend generating early upper bounds on search size by running a broad search, and extrapolating number of inclusions using initial screening.

Nested Knowledge makes it possible to conduct all major types of systematic reviews, including scoping reviews, rapid reviews, narrative reviews, meta-analyses, mixed methods reviews, and many others.

Evidence-based medicine is the notion that doctors and other healthcare providers should make decisions based on the highest quality evidence available. Generally, “in the hierarchy of evidence, systematic reviews including meta-analysis of methodologically sound RCTs with consistent results, are considered the highest level of evidence” (Guyatt, 1995)

A PRISMA diagram will be automatically generated if you complete your literature search and screening in Nested Knowledge. Click Here for more.

Yes you can! You can complete an entire review for free using the Nested Knowledge platform. To begin, [create a new account] or if you have an account, head to [AutoLit] to check out a demos or start your review. See our [getting started guide]

Nested Knowledge Basics:

Nested Knowledge allows you to complete every step of a systematic literature review and meta-analysis in one place, then automatically generates interactive visuals based on your review. Learn more about us!

Health Economics and Outcomes Research (HEOR), Systematic Literature Reviews (SLR), Clinical Evaluation Reports (CER)Learn more here!

Completing a CER can feel overwhelming, but you can use Nested Knowledge to dramatically speed up the process of gathering clinical evidence using question tags.

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Hear what they are saying about NK!

Dr. Gustam Adusumilli
Dr. Gustam AdusumilliResident in Diagnostic Radiology at Massachusetts General Hospital & Research Associate in the Heit Lab at Stanford
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I came into my first training session and the first thing that stuck out to me was how user-friendly the software is. Within a 10-15 minute span of training, I was able to pick up the platform and felt comfortable enough to get my feet wet and jump in. I also felt that the NK software acts as an umbrella for everything I need to conduct a systematic review or meta-analysis...The NK software does most of the work for the researcher.
Karim RaFaey
Karim RaFaeyZoll Medical
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“The literature search and clinical data appraisal in any CER writing process are incredibly lengthy and time-consuming. First, one has to go through different databases, search several search terms, download the results, and then go through the results to exclude the articles that are out of the scope or do not have any implications in the CER. Afterward, one has to go through the finalized articles to extract the critical data points and summarization. This process can take up to a week worth of work. However, with the Nested-Knowledge platform, this process is shortened to half a day as Nested-Knowledge combines all of these processes into one single step. All one has to do is go in and type the search terms, then Nested-Knowledge does the rest! In addition, it allows you to search different databases simultaneously and filter out duplicates with one click. It does not stop there; it can filter papers based on the preferred selection criteria, and finally, it has the capability of exporting any desired information at any point in your preferred format.”
Saraswathi Lakkasani, M.D.
Saraswathi Lakkasani, M.D.Saint Michael's Medical Center
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It's an amazing platform for the medical students, residents, and fellows for their research work with great background of statistics and extremely talented technicians.