Nested Knowledge Blog
A blog about systematic literature reviews?
Yep, you read that right. We started making software for conducting systematic reviews because we like doing systematic reviews. And we bet you do too.
If you do, check out this featured post, as well as other recent posts below, and come back often! We post all the time about best practices, new software features, and upcoming collaborations (that you can join!).
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JAMA’s Updated AI Guidance: What It Means for Authors Using Evidence Synthesis Tools
On August 10, 2026, JAMA and the JAMA Network published updated guidance for author use of AI in medical publication, authored by Annette Flanagin et al. It’s the second major revision to JAMA’s AI policy since 2024, and it tightens
More Recent Posts

JAMA’s Updated AI Guidance: What It Means for Authors Using Evidence Synthesis Tools
On August 10, 2026, JAMA and the JAMA Network published updated guidance for author use of AI in medical publication, authored by Annette Flanagin et al. It’s the second major revision to JAMA’s AI policy since 2024, and it tightens

How to Handle HTACG General Principles on AI in JCA Dossiers
On 15 July 2026, the Member State Coordination Group on Health Technology Assessment (HTACG) adopted its general principles for the use of AI in preparing dossiers for Joint Clinical Assessment. It runs three pages. Read it here: General principles on

How Cochrane’s Rapid Reviews Methods Group Sets Boundaries for AI Use
On November 24, 2025, the Cochrane Rapid Reviews Methods Group (RRMG) published a position statement in Cochrane Evidence Synthesis and Methods addressing how artificial intelligence should be used in rapid reviews. The statement was prompted by a fast-moving evidence base.

Responsible AI in Evidence Synthesis: From Principles to Practice
Systematic reviews are among the most trustworthy artifacts in medical research: a structured, reproducible synthesis of everything known about a question, built specifically so that a clinician, a guideline panel, or a regulator can rely on it. But, they’re slow.

Q3 Product Roadmap – A Letter from the Product Team
Welcome to Nested Knowledge’s first ever prospective product development post! This has been long overdue. Historically, we’ve pushed release notes as they occur, and careful listeners maybe gleaned upcoming features from our videos, blog, and trainings. As usership, product capabilities,

AI meets Tagging meets Workbooks with Nested Knowledge’s ‘Index Tables’
If you have reached the end of a systematic review and spent days reformatting extracted data to fit your intended final workbook structure, you already understand the problem Index Tables are designed to solve. Most extraction workflows are built around