Not Systematic? That’s Ok!

Any medical researcher can tell you that systematic reviews are hard. It’s not just the difficulty of building out a research question/protocol/search strategy that is intimidating—there is also simply a large burden in screening and extraction to ensure the true comprehensiveness of the studies and data collected. However, not all questions are appropriate for systematic […]

10 Things to Keep in Mind When Setting Up Your First Nest

1. Understand What Nested Knowledge Is and What It Does Before you dive into all that Nested Knowledge (NK) has to offer, you should understand the two-fold nature of the software platform: AutoLit, and Synthesis. AutoLit is the workflow portion, enabling researchers to generate high-quality evidence, like systematic reviews and meta-analyses. Synthesis is the visualization, […]

Can ChatGPT Do Your Next Systematic Review?

I started where any literature review starts–by trying to construct a Search. I wanted to see if ChatGPT could generate a PubMed query that would yield similar initial search results to a human’s initial search string. I figured it would be easiest to simply try to replicate the initial search from a recently published review conducted by our research team in collaboration with two physicians from Stanford.

New Sources of Recurring Revenue for CROs: A case study from Nested Knowledge

Secret Formula for Systematic Reviews

Tech, meet experts. It’s a powerful force multiplier: using Nested Knowledge’s intelligent systematic review and evidence visualization software, experts at a top clinical research organization have built a living evidence library for their client, a leading pharmaceutical company in the diabetes space.

Why You Should Use Tagging Hierarchies?

December 6, 2022 How Nested Knowledge users harmonize data, structure study content, and build expert knowledge into the platform. When reviewing the medical literature, the general set of steps are usually constructed as: Search for studies (on PubMed, Embase, and similar), Screen to include relevant articles (sometimes with multi-step or dual screening methods), Extract data […]

PRISMA Flow Diagram: How publications ‘flow’ through the updated PRISMA 2020 process and chart

PRISMA Flow Diagram Example

The PRISMA Flow Diagram has become a standard part of any systematic review or meta-analysis, and with good reason– it is the most widely accepted method to show the process by which the studies included in a review were included (or excluded). It also shows the different possible steps of a review, different potential sources (from PubMed to ‘expert recommendations’), and the exact reasons you set up to differentiate the wheat from the chaff among the studies you examined.

Test driving Systematic Review software: What does “Feature Complete” look like?

Systematic Review Software Comparison

Though there are over 240 tools for systematic review on the SR Toolbox, only 24 are functioning, web-based softwares for pre-clinical or clinical review. These range from academic projects to COVID-inspired living visualizations, so not every tool was intended to cover every feature recommended by Mierden/Harrison/Marshall/Kohl, but all tools cover the essential steps of adding studies, screening, and extracting and presenting some sort of review data. Table 4 in the Results section of our freely available feature assessment lays out all the options.


Data extraction, cells

June 3, 2022 This help article is about performing data extraction for meta-analyses in the NK Platform. If you just want basic instructions, feel free to check out this part of our wiki.  Meta-Analytical Extraction is quite contentious at NK. It is one of those things you either love or hate with the fire of […]

Paper Spotlight: Mechanical Thrombectomy in Anterior vs. Posterior Stroke

Research question concept map

May 25, 2022 Let’s take a quick peek at an actual manuscript published using our software. Check it out! Seeing a manuscript through to publication is stressful. You have spent months searching, screening, extracting, analyzing, and writing to be at the whim of some random peer reviewers who don’t see your manuscript as the masterpiece […]