Rapid Review for the Life Sciences
Background In clinical research and strategic decision-making, speed and accuracy in synthesizing evidence are crucial. Traditional systematic literature reviews (SLRs) can take weeks or months, slowing insights into emerging therapeutic areas. To address this challenge, a global life sciences team commissioned Nested Knowledge to run an AI-assisted rapid review on a critical biomarker and therapeutic […]
How Smart Study Type Tags Are Reinventing Evidence Synthesis
One of the features of Core Smart Tags is Smart Study Type – this refers to our AI system that automatically categorises the study type (design) of a given abstract. Knowing the study type is beneficial for a variety of reasons; most importantly filtering out studies that do not match the SLR protocol (which quite […]
IEGPs: The Bridge Between Medical Affairs and HEOR
Integrated Evidence Generation Plans (IEGPs) are meant to be the connective tissue across the product lifecycle. Strategic, collaborative plans that guide when, where, and how to generate evidence. In theory, they’re working documents that evolve with your asset. In practice? They’re often PowerPoints filed away on SharePoint, glanced at during meetings, and quickly outdated. But […]
No Trial Left Behind: Streamlining Clinical Trial Evidence for Systematic Review
When a clinical trial evaluates a novel drug or uncovers a change in medical best practices, the results are often published in a widely-read scientific journal, like JAMA, Lancet, or the NEJM. Even trials that don’t unveil the next blockbuster drug are vital. Trials showing no effect compared to placebo, so-called “negative” or inconclusive trials, […]
How is SLR used in HTA? A Primer from Nested Knowledge
Why Systematic Literature Reviews Matter in HTA Health Technology Assessment (HTA) decisions are only as strong as the evidence that supports them. That’s why systematic literature reviews (SLRs) are a core requirement across global HTA frameworks. They provide a transparent, reproducible foundation for evaluating the safety, efficacy, and cost-effectiveness of medical interventions. HTA decisions are […]
Canada’s AI Guidance for Systematic Reviews: What CDA’s Position Means for Researchers and HTA Submissions
Back in 2024,when the UK’s NICE released its position statement on the use of artificial intelligence (AI) in health technology assessments (HTAs), Nested Knowledge responded quickly, showing how our platform already aligns with the responsible use of AI in evidence generation. Now, Canada’s Drug Authority (CDA) has followed suit, releasing its own guidance on AI […]
The Best Questions to Ask Yourself When Starting a Review
At Nested Knowledge, we often say that the difference between a successful and failed evidence synthesis project comes down to how well the Research Question is scoped. Before even launching a review, the most important decision you can make is to clearly define what you are seeking to find and extract– and also what you […]
Bridging Borders: Enhancing Health Technology Assessment (HTAs) Across Geographies
Introduction Health Technology Assessment (HTA) has long been a foundational process in global healthcare systems, serving to evaluate the clinical and economic value of medical interventions and guide coverage, reimbursement, and policy decisions. While HTA is practiced globally, the frameworks and standards vary significantly by region—often requiring manufacturers and market access teams to navigate a […]
Curestack and Nested Knowledge Announce Strategic Partnership to Power End-to-End Evidence Generation from Real-World Data to Regulatory Submission
Curestack, a leader in real-world data (RWD) infrastructure and AI-powered clinical data platforms, and Nested Knowledge, the premier software platform for living systematic literature reviews and automated evidence synthesis, today announced a strategic partnership to address the growing evidence demands of health technology assessment (HTA), including Joint Clinical Assessment (JCA) requirements in the European Union and the Inflation Reduction Act (IRA) in the United States.
What You Might Have Missed at ISPOR 2025
Ahead of ISPOR 2025, Nested Knowledge took a major step forward in ensuring our mission of making evidence smarter, more accessible, and more transparent with three strategic partnerships with some of the most forward-thinking organizations in the industry. Curta With a variety of expertise in Health Policy, Market Access, Medical Affairs, and Commercial Strategy, Curta […]
