Responsible AI in Evidence Synthesis: How Nested Knowledge Meets the New Standards from Cochrane Joint Statement and RAISE Guidelines
The past year has seen a surge in global attention on the responsible use of AI in systematic reviews. With Cochrane, academic groups, and regulatory-adjacent bodies releasing clearer guidance, including new summaries of the RAISE framework, research organizations are being asked to show exactly how their AI works, how it is evaluated, and where its […]
13 Rapid Reviews in Record Time: Inside the AI-Powered Case Study
13 Rapid Reviews in Record Time: Inside the AI-Powered Case Study Background A global research team sought rapid, structured insights across multiple emerging oncological therapeutic areas (some in rare disease). The goal was to build early-stage evidence assets covering clinical, epidemiologic, and economic evidence available on the research team’s therapies and all comparators in each […]
Where Can You Find Us At ISPOR EU 2025?
Nested Knowledge at ISPOR Europe 2025: Advancing AI in Evidence Synthesis Nested Knowledge is proud to have a major presence at ISPOR Europe 2025, with multiple panels and posters highlighting the validation, application, and impact of artificial intelligence (AI) in health technology assessment (HTA), evidence synthesis, and payer decision-making. From independent validation studies to expert […]
Rapid Review for the Life Sciences
Background In clinical research and strategic decision-making, speed and accuracy in synthesizing evidence are crucial. Traditional systematic literature reviews (SLRs) can take weeks or months, slowing insights into emerging therapeutic areas. To address this challenge, a global life sciences team commissioned Nested Knowledge to run an AI-assisted rapid review on a critical biomarker and therapeutic […]
IEGPs: The Bridge Between Medical Affairs and HEOR
Integrated Evidence Generation Plans (IEGPs) are meant to be the connective tissue across the product lifecycle. Strategic, collaborative plans that guide when, where, and how to generate evidence. In theory, they’re working documents that evolve with your asset. In practice? They’re often PowerPoints filed away on SharePoint, glanced at during meetings, and quickly outdated. But […]
How is SLR used in HTA? A Primer from Nested Knowledge
Why Systematic Literature Reviews Matter in HTA Health Technology Assessment (HTA) decisions are only as strong as the evidence that supports them. That’s why systematic literature reviews (SLRs) are a core requirement across global HTA frameworks. They provide a transparent, reproducible foundation for evaluating the safety, efficacy, and cost-effectiveness of medical interventions. HTA decisions are […]
Canada’s AI Guidance for Systematic Reviews: What CDA’s Position Means for Researchers and HTA Submissions
Back in 2024,when the UK’s NICE released its position statement on the use of artificial intelligence (AI) in health technology assessments (HTAs), Nested Knowledge responded quickly, showing how our platform already aligns with the responsible use of AI in evidence generation. Now, Canada’s Drug Authority (CDA) has followed suit, releasing its own guidance on AI […]
The Best Questions to Ask Yourself When Starting a Review
At Nested Knowledge, we often say that the difference between a successful and failed evidence synthesis project comes down to how well the Research Question is scoped. Before even launching a review, the most important decision you can make is to clearly define what you are seeking to find and extract– and also what you […]
Bridging Borders: Enhancing Health Technology Assessment (HTAs) Across Geographies
Introduction Health Technology Assessment (HTA) has long been a foundational process in global healthcare systems, serving to evaluate the clinical and economic value of medical interventions and guide coverage, reimbursement, and policy decisions. While HTA is practiced globally, the frameworks and standards vary significantly by region—often requiring manufacturers and market access teams to navigate a […]
What You Might Have Missed at ISPOR 2025
Ahead of ISPOR 2025, Nested Knowledge took a major step forward in ensuring our mission of making evidence smarter, more accessible, and more transparent with three strategic partnerships with some of the most forward-thinking organizations in the industry. Curta With a variety of expertise in Health Policy, Market Access, Medical Affairs, and Commercial Strategy, Curta […]
