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Automating Clinical Trial Planning with Nested Knowledge

April 26, 2023

Nested Knowledge & Adaptic Health are combining forces to maximize chances of clinical trial success.

Nested Knowledge, a platform for structuring clinical literature and auto-generating interactive outputs, is pairing with Adaptic Health, an application for modeling recruitment, timelines, and cost in the clinical trial development process.


Clinical trial planning can be burdensome. It is time-intensive and fragmented; keeping track of multiple teams doing duplicative work across multiple platforms can be challenging. And, more often than not, the planning process is static. When new evidence is published, handling these updates can take as long as setting up the plan itself. The need for transparent, replicable methods for accessing updateable evidence is ongoing and demanding.


The solution is utilizing Nested Knowledge’s API to automatically pull new applicable clinical trials as soon as they’re published to stay updated, the streamlining of inclusion criteria and endpoints, and automatic outputs in Adaptic Health’s Research Pipelines:

Image shows Nested Knowledge automated, interactive outputs displayed on the Adaptic Health site as a direct step in the clinical trial planning process.

“By combining our respective expertise, we are confident that we can streamline clinical trial planning and execution and ultimately bring new treatments to patients more quickly,” said Luke Stewart, CEO of Adaptic Health. 

Incorporating Nested Knowledge’s auto-generated interactive outputs into Adaptic Health’s trial pipeline is a turning point for both companies. In particular, this collaboration will significantly reduce time and cost of clinical trial design equipping Chief Medical Officers (CMOs) and clinical teams with the best chances of success. From Nested Knowledge CEO, Kevin Kallmes: “At Nested Knowledge, we have been excited to provide easy access to patient population and endpoint mapping, but the Adaptic model builds so much more on top of it– really, it helps you learn from the mistakes and the successes of past trials and model realistic scenarios from that data.”

About Nested Knowledge

Nested Knowledge is a living evidence platform that houses, auto-generates, and analyzes published clinical literature for conducting systematic literature reviews. As a result, each review produces evidence as interactive, web-based visuals. The platform emphasizes updateability, traceability, and visual interactivity– revolutionizing the way evidence is understood, no more scattered, non-updatable, incomplete PDFs. 

For more information, visit

About Adaptic Health

Adaptic Health is a platform that helps organizations structure clinical trial planning and development through all stages from design to biostatistical optimization. The application enables ease of collaboration, review of current and up-to-date literature, and simulates design trade-offs, reducing the time and cost of clinical trial design by up to six months and saving millions of dollars.

For more information, visit

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